LDMgen is a small, easy to use, command prompt based application specially designed to offer users a tool to help you map the disease gene (including location and confidence interval) by using multisite genotype data of case-control studies. The. ...
- ldmgen.zip
- Hongyu Zhao
- Freeware (Free)
- WindowsAll
The application loads microarray data (gene expression ratios) and determines which genes are up- or downregulated by a user-defined ratio cut-off level.For each experiment, lists of differentially expressed genes are computed. Every list will be. ...
- program.zip
- Marcel Smid
- Freeware (Free)
- Windows All
Easily create HTML image maps with this friendly photo and image map editor. Pos HTML Image Mapper includes WYSIWYG interface allowing you mapping images fast and easy.
- PosHTMLImageMapper_SetUp.exe
- PowerOfSoftware Ltd.
- Shareware ($24.90)
- 103 Kb
- Win98, WinME, WinXP, Windows Vista, Windows
Gene Visualizer is a small app designed to display an organism's genes visually. The program takes two sets of genes as input. One is a list of an organism's predicted genes, and the other is a list of an organism's known genes. It can be useful to. ...
- GeneVisualizer.jar
- Andy Hou
- Freeware (Free)
- WindowsAll
ncRNA Mapper is a computer program that gives more insight in the localization of sequencing fragments.Given that sequencing of RNA gives reads at fixed base-positions, ncRNA Mapper analyzes the alignments (generated by Short Sequence Location. ...
- ncRNA_Mapper.zip
- Youri Hoogstrate
- Freeware (Free)
- Windows All
Short Sequence Location Mapper loads the sequences, then aligns them and finally graphs and tables can be generated for one or more datasets at the same time.SSLM typically works with a BLAST data output file of short Solexa reads mapped to RNA. ...
- SSLM.zip
- Bas Pigmans
- Freeware (Free)
- Windows All
TB antibiotic resistance mapper was developed as a specialized tool that can help you map sequencing reads with the MTB reference genome (H37Rv) using NCBI blast, in order to find out mutation sites. Now you can quickly discover mutations with the. ...
- TBARMapper.zip
- Xi Yang
- Freeware (Free)
- Windows All
Advance image mapping software is economical tool that enable user to create and export image maps to web page. Html graphics mapper application contains interactive GUI that helps user in operating features and functionality of software. ...
- Professional Html PicturesMapper Tool
- Software How to
- Shareware ($19.90)
- 10 Kb
- Win98, WinME, WinNT 3.x, WinNT 4.x, Windows2000, WinXP, Windows2003,Windows Vista
The Random Sample Mapper application was developed to be a small tool that moves random samples to a folder and makes an SFZ file..
- rANdoMSaMPles.jar
- Jeremy Wentworth
- Shareware ($)
- 30 Kb
- Win All
MicrosoftdlTﾃつｫ SQL Server View Mapper enables you to produce an XML View schema file that relates an XDR schema to a SQL Server schema. MicrosoftdlTﾂｫ SQL Server View Mapper enables you to produce an XML View schema file that relates an XDR schema to a SQL Server schema. Using this tool and the documentation requires a working knowledge of both XML and database concepts and terminology.
- setup.exe
- Microsoft
- Shareware ($)
- 4.53 Mb
- WinXP, Win2000, Win Vista, Windows 7, Windows 7 x64
With Simple Warehouse Mapper you can create a visual representation. Our free Simple Warehouse Mapper uses a simple 3D simulation technique known as Isometric maps to provide a realistic view of a distribution center or factory. With Simple Warehouse Mapper you can create a visual representation of your facility and add process information directly to the picture.
- SimpleWarehouseMapper.msi
- Wild Mouse Software
- Shareware ($)
- 737 Kb
- WinXP, Win2000, Win Vista
CoffeeCup Image Mapper has mouseover HTML capability, includes a fully functional image map wizard, and enables users to attach parts of an image to different links. Image Mapper can map any noninterlaced .gif, interlaced .
- CoffeeMap42.exe
- CoffeeCup Software, Inc.
- Shareware ($)
- 3.84 Mb
- WinXP, Win2003, Win2000, Win Vista, Windows 7
- Gene Marker Software For Mac Free
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- Gene Marker Software For Mac Free
- Gene Marker Software For Mac Windows 10
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Gene Marker Software Wormbase Converter v.1.0 Wormbase Converter is a simple, easy to use application designed to help you with the conversion of any Gene ID into any other Gene ID. Sep 10, 2007 I've put together this list of 10 pieces of free molecular biology software for Macs. I hope you will find at least some of it useful. If you any of your favorite free programs are not included, please e-mail me and I'll add them or you can leave a comment with a link. If you are a PC user, click here for the PC list. Serial Cloner Serial Cloner is fantastic all-in-one workbench; import.
Related:Gene Mapper - Abi Gene Mapper - Gene Mapper Free - Rotor Gene - Gene Rally
A genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species. It can be described as a variation (which may arise due to mutation or alteration in the genomic loci) that can be observed. A genetic marker may be a short DNA sequence, such as a sequence surrounding a single base-pair change (single nucleotide polymorphism, SNP), or a long one, like minisatellites.
Background[edit]
For many years, gene mapping was limited to identifying organisms by traditional phenotype markers. This included genes that encoded easily observable characteristics such as blood types or seed shapes. The insufficient number of these types of characteristics in several organisms limited the mapping efforts that could be done. This prompted the development of gene markers which could identify genetic characteristics that are not readily observable in organisms (such as protein variation).[1]
Types[edit]
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Some commonly used types of genetic markers are:
- RFLP (or Restriction fragment length polymorphism)
- SSLP (or Simple sequence length polymorphism)
- AFLP (or Amplified fragment length polymorphism)
- RAPD (or Random amplification of polymorphic DNA)
- VNTR (or Variable number tandem repeat)
- SSR Microsatellite polymorphism, (or Simple sequence repeat)
- SNP (or Single nucleotide polymorphism)
- STR (or Short tandem repeat)
- SFP (or Single feature polymorphism)
- DArT (or Diversity Arrays Technology)
- RAD markers (or Restriction site associated DNA markers)
Molecular genetic markers can be divided into two classes a) biochemical markers which detect variation at the gene product level such as changes in proteins and amino acids and b) molecular markers which detect variation at the DNA level such as nucleotide changes: deletion, duplication, inversion and/or insertion. Markers can exhibit two modes of inheritance, i.e. dominant/recessive or co-dominant. If the genetic pattern of homo-zygotes can be distinguished from that of hetero-zygotes, then a marker is said to be co-dominant. Generally co-dominant markers are more informative than the dominant markers.[2]
Uses[edit]
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Genetic markers can be used to study the relationship between an inherited disease and its genetic cause (for example, a particular mutation of a gene that results in a defective protein). It is known that pieces of DNA that lie near each other on a chromosome tend to be inherited together. This property enables the use of a marker, which can then be used to determine the precise inheritance pattern of the gene that has not yet been exactly localized.
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Genetic markers are employed in genealogical DNA testing for genetic genealogy to determine genetic distance between individuals or populations. Uniparental markers (on mitochondrial or Y chromosomal DNA) are studied for assessing maternal or paternal lineages. Autosomal markers are used for all ancestry.
Genetic markers have to be easily identifiable, associated with a specific locus, and highly polymorphic, because homozygotes do not provide any information. Detection of the marker can be direct by RNA sequencing, or indirect using allozymes.
Some of the methods used to study the genome or phylogenetics are RFLP, AFLP, RAPD, SSR. They can be used to create genetic maps of whatever organism is being studied.
There was a debate over what the transmissible agent of CTVT (canine transmissible venereal tumor) was. Many researchers hypothesized that virus like particles were responsible for transforming the cell, while others thought that the cell itself was able to infect other canines as an allograft. With the aid of genetic markers, researchers were able to provide conclusive evidence that the cancerous tumor cell evolved into a transmissible parasite. Furthermore, molecular genetic markers were used to resolve the issue of natural transmission, the breed of origin (phylogenetics), and the age of the canine tumor.[3]
Genetic markers have also been used to measure the genomic response to selection in livestock. Natural and artificial selection leads to a change in the genetic makeup of the cell. The presence of different alleles due to a distorted segregation at the genetic markers is indicative of the difference between selected and non-selected livestock.[4]
References[edit]
- ^Benjamin A. Pierce (2013-12-27). Genetics: A Conceptual Approach. Macmillan Learning. ISBN978-1-4641-0946-1.
- ^N Manikanda Boopathi (2012-12-12). Genetic Mapping and Marker Assisted Selection: Basics, Practice and Benefits. Springer Science & Business Media. pp. 60–. ISBN978-81-322-0958-4.
- ^Murgia C, Pritchard JK, Kim SY, Fassati A, Weiss RA. Clonal origin and evolution of a transmissible cancer. Cell. 2006 Aug 11;126(3):477-87.
- ^Gomez-Raya L, Olsen HG, Lingaas F, Klungland H, Våge DI, Olsaker I, Talle SB, Aasland M, Lien S (November 2002). 'The use of genetic markers to measure genomic response to selection in livestock'. Genetics. 162 (3): 1381–8. PMC1462338. PMID12454081.
See also[edit]
Further reading[edit]
- de Vicente C, Fulton T (2003). Molecular Marker Learning Modules – Vol. 1. IPGRI, Rome, Italy and Institute for Genetic Diversity, Ithaca, New York, USA.[permanent dead link]
- de Vicente C, Fulton T (2004). Molecular Marker Learning Modules – Vol. 2. IPGRI, Rome, Italy and Institute for Genetic Diversity, Ithaca, New York, USA.
- de Vicente C, Glaszmann JC (2006). Molecular Markers for Allele Mining. AMS (Bioversity's Regional Office for the Americas), CIRAD, GCP, IPGRI, M.S. Swaminathan Research Foundation. p. 85. Archived from the original on 2007-12-04. Retrieved 2007-12-12.
- Spooner D, van Treuren R, de Vicente MC (2005). Molecular markers for genebank management. CGN, IPGRI, USDA. p. 126. Archived from the original on 2008-05-03. Retrieved 2007-12-12.
External links[edit]
Gene Marker Software For Mac Windows 10
Media related to Genetic markers at Wikimedia Commons